Gewald Reaction

The Gewald Reaction Is A Synthesis Of 2-aminothiophenes Via A Multi-component Condensation Between Sulfur, An α-methylene Carbonyl Compound And An α-cyanoester.

Mechanism Of The Gewald Reaction

First Step In The Process Is A Knoevenagel Condensation, But The Remainder Of The Sequence Is Not Known In Detail:

Recent Literature

An Efficient Synthesis Of 2-Aminothiophenes Via The Gewald Reaction Catalyzed By An N-Methylpiperazine-Functionalized Polyacrylonitrile Fiber
L. Ma, L. Yuan, C. Xu, G. Li, M. Tao, W. Zhang, Synthesis, 2013, 45, 45-52.

Microwave-Assisted Synthesis Of 5-Substituted 2-Aminothiophenes Starting From Arylacetaldehydes
G. Revelant, S. Dunand, S. Hesse, G. Kirsch, Synthesis, 2011, 2935-2940.

Practical Synthesis Of Tetrasubstituted Thiophenes For Use In Compound Libraries
B. P. McKibben, C. H. Cartwright, A. L. Castelhano, Tetrahedron Lett., 1999, 5471-5474.

An Efficient One-Pot Synthesis Of Substituted 2-Aminothiophenes Via Three-Component Gewald Reaction Catalyzed By L-Proline
T. Wang, X.-G. Huang, J. Liu, B. Li, J.-J. Wu, K.-X. Chen, W.-L. Zhu, X.-Y. Xu, B.-B. Zeng, Synlett, 2010, 1351-1354.

Synthesis Of Thiophene Derivatives On Soluble Polymer-Support Using Gewald Reaction
H. Zhang, G. Yang, J. Chen, Z. Chen, Synlett, 2004, 3055-3059