Williamson Synthesis

This Method Is Suitable For The Preparation Of A Wide Variety Of Unsymmetric Ethers. The Nucleophilic Substitution Of Halides With Alkoxides Leads To The Desired Products.

If The Halides Are Sterically Demanding And There Are Accessible Protons In The β-position, The Alkoxide Will Act As A Base, And Side Products Derived From Elimination Are Isolated Instead.

Mechanism Of The Williamson Synthesis