Wurtz-Fittig Reaction

This Reaction Allows The Alkylation Of Aryl Halides. The More Reactive Alkyl Halide Forms An Organosodium First, And This Reacts As A Nucleophile With An Aryl Halide As The Electrophile. Excess Alkyl Halide And Sodium May Be Used If The Symmetric Coupled Alkanes Formed As A Side Product May Be Separated Readily.

Mechanism Of The Wurtz-Fittig Reaction

Recent Literature

Preparation Of Isoindolones By A Lithium-Iodide Exchange-Induced Intra­molecular Wurtz-Fittig Reaction Of O-Iodobenzoyl Chloride/Imine Adducts
J. B. Campbell, R. F. Dedinas, S. Trumbower-Walsh, Synlett, 2010, 3008-3010.